Activation of murine macrophages by Neisseria meningitidis and IFN-gamma in vitro: distinct roles of class A scavenger and Toll-like pattern recognition receptors in selective modulation of surface phenotype.

doi:10.1189/jlb.0104014

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Activation of murine macrophages by Neisseria meningitidis and IFN-gamma in vitro: distinct roles of class A scavenger and Toll-like pattern recognition receptors in selective modulation of surface phenotype.

Journal of leukocyte biology - 1 Sept 2004

Mukhopadhyay Subhankar, Peiser Leanne, Gordon Siamon

Abstract excerpt

Innate and adaptive immune activation of macrophages (Mphi) by microorganisms and antigen-activated lymphoid cells, respectively, plays an important role in host defense and immunopathology. Antigen-presenting cells express a range of pattern recognition receptors including the class A types I and II scavenger receptors (SR-A) and Toll-like receptors (TLR). Recognition of microbial products by SR-A and TLR...

Topics

Animals
Antigens, CD
B7-1 Antigen
B7-2 Antigen
CD36 Antigens
Chemotaxis, Leukocyte
Histocompatibility Antigens Class II
Immunity, Innate
In Vitro Techniques
Inflammation Mediators

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interferon-gamma

Lectins, C-Type

Lipopolysaccharides

Macrophages

Mannose Receptor

Mannose-Binding Lectins

Membrane Glycoproteins

Mice

Source

Open in PubMed

Identifiers

PMID: 15218052
DOI: 10.1189/jlb.0104014

Genes

MARCO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of murine macrophages by Neisseria meningitidis and IFN-gamma in vitro: distinct roles of class A scavenger and Toll-like pattern recognition receptors in selective modulation of surface phenotype.PMID 15218052Read ↗

MARCO, an innate activation marker of macrophages, is a class A scavenger receptor for <i>Neisseria meningitidis</i>Semantic proximity Read ↗

Innate immune recognition and inflammation in Neisseria meningitidis infectionSemantic proximity Read ↗

Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-gamma- and CD40L-mediated costimulation.Semantic proximity Read ↗

Group A Streptococcus Activates Type I Interferon Production and MyD88-dependent Signaling without Involvement of TLR2, TLR4, and TLR9Semantic proximity Read ↗

Activation of human meningeal cells is modulated by lipopolysaccharide (LPS) and non-LPS components of Neisseria meningitidis and is independent of Toll-like receptor (TLR)4 and TLR2 signalling.Semantic proximity Read ↗

Activation of human dendritic cells is modulated by components of the outer membranes of Neisseria meningitidis.Semantic proximity Read ↗

Interleukin-4 and dexamethasone counterregulate extracellular matrix remodelling and phagocytosis in type-2 macrophages.Semantic proximity Read ↗

Differential roles of TLR2 and TLR4 in the host response to Gram-negative bacteria: lessons from a lipopolysaccharide-deficient mutant of Neisseria meningitidis.Semantic proximity Read ↗

A novel phenotype for an activated macrophage: the type 2 activated macrophage.Semantic proximity Read ↗

Mannosyl-recognizing receptors induce an M1-like phenotype in macrophages of susceptible mice but an M2-like phenotype in mice resistant to a fungal infection.Semantic proximity Read ↗

Differences in innate immune responses correlate with differences in murine susceptibility to Chlamydia muridarum pulmonary infection.Semantic proximity Read ↗

<i>Coxiella burnetii</i>, the agent of Q fever, stimulates an atypical M2 activation program in human macrophagesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.