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Article

Effect of the methylenetetrahydrofolate reductase C677T polymorphism on patients with cisplatin/gemcitabine-treated stage IV non-small-cell lung cancer.

Clinical lung cancer - 1 May 2004

Alberola Vicente, Sarries Carme, Rosell Rafael, Taron Miquel, de las Peñas Ramon, Camps Carlos, Massuti Bartomeu, Insa Amelia, Garcia-Gomez Ramon, Isla Dolores, Artal Angel, Muñoz Miguel Angel, Cobo Manuel, Bover Isabel, Gonzalez-Larria Jose Luis, Terrasa Josefa, Almenar Daniel, Barcelo Ramon, Diz Pilar, Sanchez-Ronco Maria, Sanchez Jose Javier

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in the metabolic pathways of S-adenosylmethionine have been related to global hypomethylation and a lower number of hypermethylated CpG islands of tumor suppressor genes. Hypermethylation of checkpoint and DNA repair genes has been shown to be indicative of...

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Source

Identifiers

PMID: 15217535
DOI: 10.3816/clc.2004.n.014

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15217535-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Effect of the methylenetetrahydrofolate reductase C677T polymorphism on patients with cisplatin/gemcitabine-treated stage IV non-small-cell lung cancer.PMID 15217535Read ↗

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