Correlation between polymorphisms of the reduced folate carrier gene (SLC19A1) and survival after pemetrexed-based therapy in non-small cell lung cancer: a North Central Cancer Treatment Group-based exploratory study.

doi:10.1097/JTO.0b013e3181ec18c4

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Article

Correlation between polymorphisms of the reduced folate carrier gene (SLC19A1) and survival after pemetrexed-based therapy in non-small cell lung cancer: a North Central Cancer Treatment Group-based exploratory study.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Sept 2010

Adjei Araba A, Salavaggione Oreste E, Mandrekar Sumithra J, Dy Grace K, Ziegler Katie L Allen, Endo Chiaki, Molina Julian R, Schild Steven E, Adjei Alex A

Abstract excerpt

PURPOSE: To correlate polymorphisms in genes involved in the transport, activation, and inactivation of pemetrexed with the outcome of patients with advanced non-small cell lung cancer (NSCLC) treated with pemetrexed. EXPERIMENTAL DESIGN: Data from a phase II NSCLC trial evaluating the optimal schedule of gemcitabine and pemetrexed were used. All patients with available DNA were genotyped for polymorphisms in...

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PMID: 20651609
DOI: 10.1097/JTO.0b013e3181ec18c4
PMCID: PMC5735419

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