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Article

Transcriptional regulation of cyclooxygenase-2 gene in pancreatic beta-cells.

The Journal of biological chemistry - 20 Aug 2004

Yang Fan, Bleich David

Abstract excerpt

Prostaglandin E(2) (PGE(2)) has been shown to negatively affect pancreatic beta-cell function, and its inducible synthesis is mediated in part by cycloxygenase-2 (COX-2). Regulation of basal and inducible COX-2 gene expression in pancreatic beta-cells is not fully understood. In this report, we used pancreatic beta-cells (RINm5F) to explore the molecular mechanisms regulating COX-2 promoter activity. Through...

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PMID: 15213229
DOI: 10.1074/jbc.M404055200

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EBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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