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Article

Down-regulation of key virulence factors makes the Salmonella enterica serovar Typhimurium rfaH mutant a promising live-attenuated vaccine candidate.

Infection and immunity - 1 Oct 2006

Nagy Gábor, Danino Vittoria, Dobrindt Ulrich, Pallen Mark, Chaudhuri Roy, Emödy Levente, Hinton Jay C, Hacker Jörg

Abstract excerpt

Mutants of Salmonella enterica serovar Typhimurium that lack the transcriptional regulator RfaH are efficient as live oral vaccines against salmonellosis in mice. We show that the attenuation of the vaccine candidate strain is associated with reduced net growth in epithelial and macrophage cells. In order to identify the relevant RfaH-dependent genes, the RfaH regulon was determined with S. enterica serovars...

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Identifiers

PMID: 16988271
DOI: 10.1128/IAI.00619-06
PMCID: PMC1594928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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