A Fluorescence <b> <i>in Situ</i> </b> Hybridization Map of 6q Deletions in Acute Lymphocytic Leukemia

Abstract excerpt

With the objective of identifying candidate tumor suppressor genes, we used fluorescence in situ hybridization to map leukemia-related deletions of the long arm of chromosome 6 (6q). Twenty of 24 deletions overlapped to define a 4.8-Mb region of minimal deletion between markers D6S1510 and D6S1692 within chromosome 6 band q16. Using reverse transcription-PCR, we found evidence of expression in hematopoietic cells...

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