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Article

Kaposi’s Sarcoma-Associated Herpesvirus Induction of Chromosome Instability in Primary Human Endothelial Cells

15 Jun 2004

Abstract excerpt

Chromosome instability contributes to the multistep oncogenesis of cancer cells. Kaposi's sarcoma (KS), an angiogenic vascular spindle cancer of endothelial cells, displays stage advancement with lesions at early stage being hyperproliferative, whereas lesions at late stage are clonal or multiclonal and can exhibit a neoplastic nature and chromosome instability. Although infection with KS-associated herpesvirus...

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PMID: 15205312
DOI: 10.1158/0008-5472.can-04-0657

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