Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Long-term infection and transformation of dermal microvascular endothelial cells by human herpesvirus 8.

Journal of virology - 1 Aug 1999

Moses A V, Fish K N, Ruhl R, Smith P P, Strussenberg J G, Zhu L, Chandran B, Nelson J A

Abstract excerpt

Human herpesvirus 8 (HHV8) infects Kaposi's sarcoma (KS) spindle cells in situ, as well as the lesional endothelial cells considered to be spindle cell precursors. The HHV8 genome contains several oncogenes, suggesting that infection of endothelial and spindle cells could induce cellular transformation and tumorigenesis and promote the formation of KS lesions. To investigate the potential of HHV8 infection of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Agar
Share to Antigens, Viral
Share to Cell Culture Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Transformation, Viral

Share to Endothelium, Vascular

Share to Herpesvirus 8, Human

Share to Sarcoma, Kaposi

Share to Virus Latency

Source

Open in PubMed Open full text

Identifiers

PMID: 10400787
DOI: 10.1128/JVI.73.8.6892-6902.1999
PMCID: PMC112774

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Long-term infection and transformation of dermal microvascular endothelial cells by human herpesvirus 8.PMID 10400787Read ↗

Kaposi's Sarcoma-Associated Herpesvirus Induces Sustained Levels of Vascular Endothelial Growth Factors A and C Early during In Vitro Infection of Human Microvascular Dermal Endothelial Cells: Biological ImplicationsSemantic proximity Read ↗

KSHV infection of endothelial precursor cells with lymphatic characteristics as a novel model for translational Kaposi’s sarcoma studiesSemantic proximity Read ↗

Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cellsSemantic proximity Read ↗

Kaposi Sarcoma Herpesvirus Promotes Endothelial-to-Mesenchymal Transition through Notch-Dependent SignalingSemantic proximity Read ↗

Productive infection of HUVEC by HHV-8 is associated with changes compatible with angiogenic transformations.Semantic proximity Read ↗

Latent KSHV infection of endothelial cells induces integrin beta3 to activate angiogenic phenotypes.Semantic proximity Read ↗

Activation of NF-kappaB by the latent vFLIP gene of Kaposi's sarcoma-associated herpesvirus is required for the spindle shape of virus-infected endothelial cells and contributes to their proinflammatory phenotype.Semantic proximity Read ↗

iTIME.219: An Immortalized KSHV Infected Endothelial Cell Line Inducible by a KSHV-Specific Stimulus to Transition From Latency to Lytic Replication and Infectious Virus ReleaseSemantic proximity Read ↗

Kaposi’s Sarcoma-Associated Herpesvirus Induction of Chromosome Instability in Primary Human Endothelial CellsSemantic proximity Read ↗

Kaposi's sarcoma herpesvirus-induced endothelial cell reprogramming supports viral persistence and contributes to Kaposi's sarcoma tumorigenesisSemantic proximity Read ↗

Spindle Cell Conversion by Kaposi's Sarcoma-Associated Herpesvirus: Formation of Colonies and Plaques with Mixed Lytic and Latent Gene Expression in Infected Primary Dermal Microvascular Endothelial Cell CulturesSemantic proximity Read ↗

De Novo Infection and Serial Transmission of Kaposi's Sarcoma-Associated Herpesvirus in Cultured Endothelial CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.