Modeling amyloid beta-peptide insertion into lipid bilayers.

Abstract excerpt

Inspired by recent suggestions that the Alzheimer's amyloid beta peptide (Abeta) can insert into cell membranes and form harmful ion channels, we model insertion of the 40- and 42-residue forms of the peptide into cell membranes using a Monte Carlo code which is specific at the amino acid level. We examine insertion of the regular Abeta peptide as well as mutants causing familial Alzheimer's disease, and find...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Amyloid beta-Peptides
• Share to Cell Membrane