Article
Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium.
Blood - 15 Sept 2004
Göthert Joachim R, Gustin Sonja E, van Eekelen J Anke M, Schmidt Uli, Hall Mark A, Jane Stephen M, Green Anthony R, Göttgens Berthold, Izon David J, Begley C Glenn
Abstract excerpt
Tumor growth is dependent in part on "neoangiogenesis." Functional involvement of bone marrow (BM)-derived cells in this process has been demonstrated. However, it remains controversial as to whether tumor endothelium itself is BM derived. Here we sought to address this issue with an endothelial-specific, inducible transgenic model. We generated Cretransgenic mice (endothelial-SCL-Cre-ER(T)) using the...
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