Article
Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm.
Journal of biology - 1 Jan 2004
Okubo Tadashi, Hogan Brigid L M
Abstract excerpt
BACKGROUND: Studies in many model systems have shown that canonical signaling through the pathway downstream of ligands of the Wnt family can regulate multiple steps in organogenesis, including cell proliferation, differentiation, and lineage specification. In addition, misexpression of the Wnt-family member Wingless in Drosophila imaginal disc cells can lead to transdetermination of progenitors from one lineage...
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