Article
Carvedilol but not metoprolol reduces beta-adrenergic responsiveness after complete elimination from plasma in vivo.
Circulation - 29 Jun 2004
Kindermann Michael, Maack Christoph, Schaller Susanne, Finkler Nadine, Schmidt Kathrin I, Läer Stephanie, Wuttke Henrike, Schäfers Hans-Joachim, Böhm Michael
Abstract excerpt
BACKGROUND: Carvedilol but not metoprolol exhibits persistent binding to beta-adrenergic receptors (beta-ARs) even after washout in cell culture experiments. Here, we determined the significance of this phenomenon on human beta-ARs in vitro and in vivo. METHODS AND RESULTS: Experiments were conducted on human atrial trabeculae (n=8 to 10 per group). In the presence of metoprolol, isoproterenol potency was reduced...
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