Article
The tau R406W mutation causes progressive presenile dementia with bitemporal atrophy.
Dementia and geriatric cognitive disorders - 1 Jan 2004
Ostojic Jovanka, Elfgren Christina, Passant Ulla, Nilsson Karin, Gustafson Lars, Lannfelt Lars, Froelich Fabre Susanne
Abstract excerpt
Frontotemporal dementia (FTD) and Alzheimer's disease (AD) are two frequent causes of dementia that share both clinical and neuropathological features. Common to both disorders are the neurofibrillary tangles consisting of aggregations of hyperphosphorylated tau protein. Recently, a number of different pathogenic mutations in the tau gene have been identified in families with FTD and parkinsonism linked to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.