Article
Genetic basis of drug-induced arrhythmias.
Annals of medicine - 1 Jan 2004
Vos Marc A, Paulussen Aimée D C
Abstract excerpt
Drug-induced torsade de pointes arrhythmia (TdP) is frequently seen in patients. This proarrhythmia is not restricted to anti-arrhythmics but includes a variety of drugs. A genetic predisposition is an attractive explanation for this clinical problem. In this review, we: 1) explain the arrhythmogenic mechanisms of TdP, 2) provide data for a genetic cause based upon mutations in the long QT or in cytochrome genes...
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