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Article

Use of RNA Interference to Prevent Lethal Murine West Nile Virus Infection

12 Mar 2005

Abstract excerpt

West Nile virus causes fatal encephalitis in humans, mice, and other vertebrates. In the present study, we demonstrate that small interfering RNAs (siRNAs) inhibit West Nile virus replication in vitro. Moreover, the administration of siRNAs to mice by hydrodynamic injection 24 h before challenge with an intraperitoneal inoculum of West Nile virus reduced the viral load and afforded partial protection from lethal...

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PMID: 15747251
DOI: 10.1086/428507

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