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Host gene targets for novel influenza therapies elucidated by high‐throughput RNA interference screens

12 Jan 2012

Abstract excerpt

Influenza virus encodes only 11 viral proteins but replicates in a broad range of avian and mammalian species by exploiting host cell functions. Genome‐wide RNA interference (RNAi) has proven to be a powerful tool for identifying the host molecules that participate in each step of virus replication. Meta‐analysis of findings from genome‐wide RNAi screens has shown influenza virus to be dependent on functional...

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PMID: 22247330
DOI: 10.1096/fj.11-193466

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