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Article

Human BAC-mediated rescue of the Friedreich ataxia knockout mutation in transgenic mice.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 May 2004

Sarsero Joseph P, Li Lingli, Holloway Timothy P, Voullaire Lucille, Gazeas Sophie, Fowler Kerry J, Kirby Denise M, Thorburn David R, Galle Adam, Cheema Surindar, Koenig Michel, Williamson Robert, Ioannou Panos A

Abstract excerpt

Three independent transgenic mouse lines were generated with the human Friedreich ataxia gene, FRDA, in an 188-kb bacterial artificial chromosome (BAC) genomic sequence. Three copies of the transgene per diploid mouse genome were integrated in a single site in each mouse line. Transgenic mice were mated with mice heterozygous for a knockout mutation of the murine Frda gene, to generate mice homozygous for the...

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Source

Identifiers

PMID: 15170226
DOI: 10.1007/s00335-004-3019-3

Genes

GAA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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