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Autophagosome-like vacuole formation in Huntingtonʼs disease lymphoblasts

1 Jun 2004

Abstract excerpt

In an effort to clarify cellular abnormalities in Huntington's disease without the confounding factor of gross degeneration and postmortem alterations associated with studies of the brain, we have examined HD patient lymphoblasts. We report pronounced vacuole formation in patients. The vacuoles possess huntingtin remnants and cathepsin B staining, a lysosomal marker, suggesting autophagy. The number and size of...

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PMID: 15167559
DOI: 10.1097/01.wnr.0000127073.66692.8f

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