In rat brain amoxapine enhances dopamine metabolism: pharmacokinetic variations of the effect.

doi:10.1016/0014-2999(92)90606-5

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Article

In rat brain amoxapine enhances dopamine metabolism: pharmacokinetic variations of the effect.

European journal of pharmacology - 29 Apr 1992

Kobayashi A, Fujita K, Nakazawa K

Abstract excerpt

When rats were given i.p. amoxapine, the drug was biotransformed to 7-hydroxyamoxapine, but not to 8-hydroxyamoxapine. The maximal concentrations of amoxapine and 7-hydroxyamoxapine in the serum and brain were found 30 min after the single injection, and the concentration of the former in the bra...

Topics

3,4-Dihydroxyphenylacetic Acid
Amoxapine
Animals
Brain
Corpus Striatum
Dopamine
Drug Synergism
Frontal Lobe
Genetic Variation
Homovanillic Acid
Male
Methoxyhydroxyphenylglycol
Norepinephrine
Rats
Rats, Inbred Strains

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