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Article

Plasticity of extended subsites facilitates divergent substrate recognition by Kex2 and furin.

The Journal of biological chemistry - 20 Aug 2004

Rozan Laura, Krysan Damian J, Rockwell Nathan C, Fuller Robert S

Abstract excerpt

Yeast Kex2 and human furin are subtilisin-related proprotein convertases that function in the late secretory pathway and exhibit similar though distinguishable patterns of substrate recognition. Although both enzymes prefer Arg at P(1) and basic residues at P(2), the two differ in recognition of P(4) and P(6) residues. To probe P(4) and P(6) recognition by Kex2p, furin-like substitutions were made in the putative...

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Identifiers

PMID: 15159396
DOI: 10.1074/jbc.M405362200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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