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Article

The anti-ischemia agent ranolazine promotes the development of intestinal tumors in APC(Min/+) mice.

Cancer letters - 25 Jun 2004

Suckow Mark A, Gutierrez Linda S, Risatti Christina A, Wolter William R, Taylor Richard E, Pollard Morris, Navari Rudolph M, Castellino Francis J, Paoni Nicholas F

Abstract excerpt

Ranolazine was shown to improve exercise parameters in patients with chronic angina. It works by switching myocardial energy metabolism from fatty acids to glucose, thus increasing the efficiency of ATP production under hypoxic conditions. Tumors are hypoxic and may also respond to ranolazine. We found that ranolazine caused a dose-dependent increase in tumor number in APC(Min/+) mice, a model of spontaneous...

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Share to Adenomatous Polyposis Coli
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15159018
DOI: 10.1016/j.canlet.2004.01.007

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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