Article
HPV18 E6 and E7 genes affect cell cycle, pRB and p53 of cervical tumor cells and represent prominent candidates for intervention by use peptide nucleic acids (PNAs).
Cancer letters - 8 Jun 2004
Braun Klaus, Ehemann Volker, Waldeck Waldemar, Pipkorn Rüdiger, Corban-Wilhelm Heike, Jenne Jürgen, Gissmann Lutz, Debus Jürgen
Abstract excerpt
Approximately 100% of cervical carcinomas are causally linked to infections with high-risk human papillomaviruses (HPVs), whose oncogenicity has been assigned to the continued expression of two early viral genes, E6 and E7. Reversal of the transformed phenotype by inhibiting E6/E7 gene expression therefore provides a suitable goal for tumor therapy. We established an application controlling the E6/E7 expression...
Topics
- Algorithms
- Base Sequence
- Cell Cycle
- DNA
- DNA-Binding Proteins
- Disulfides
- Female
- Flow Cytometry
- HeLa Cells
- Humans
- Molecular Sequence Data
- Oncogene Proteins, Viral
- Peptide Nucleic Acids