Article
Failure to clear persistent vaccine-derived neurovirulent poliovirus infection in an immunodeficient man.
Lancet (London, England) - 8 May 2004
MacLennan Calman, Dunn Glynis, Huissoon Aarnoud P, Kumararatne Dinakantha S, Martin Javier, O'Leary Paula, Thompson Ronald A, Osman Husam, Wood Philip, Minor Philip, Wood David J, Pillay Deenan
Abstract excerpt
BACKGROUND: Individuals who chronically excrete neurovirulent poliovirus of vaccine-origin are of considerable concern to the Global Polio Eradication programme. Chronic infection with such polioviruses is a recognised complication of hypogammaglobulinaemia. METHODS: We did a series of in-vitro and in-vivo therapeutic studies, with a view to clearing persistent neurovirulent poliovirus infection in an individual...
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