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Growth Differentiation Factor 9 Regulates Expression of the Bone Morphogenetic Protein Antagonist Gremlin

1 Jul 2004

Abstract excerpt

Growth differentiation factor 9 (GDF9) is an oocyte-expressed member of the transforming growth factor beta (TGF-beta) superfamily and is required for normal ovarian follicle development and female fertility. GDF9 acts as a paracrine factor and affects granulosa cell physiology. Only a few genes regulated by GDF9 are known. Our microarray analysis has identified gremlin as one of the genes up-regulated by GDF9 in...

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PMID: 15133038
DOI: 10.1074/jbc.m403212200

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Growth Differentiation Factor 9 Regulates Expression of the Bone Morphogenetic Protein Antagonist GremlinPMID 15133038Read ↗

Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligandsSemantic proximity Read ↗

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GDF9 is Transiently Expressed in Oocytes before Follicle Formation in the Human Fetal Ovary and is Regulated by a Novel NOBOX TranscriptSemantic proximity Read ↗

Growth differentiation factor-9 is required during early ovarian folliculogenesisSemantic proximity Read ↗

Human Growth Differentiation Factor 9 (GDF-9) and Its Novel Homolog GDF-9B Are Expressed in Oocytes during Early FolliculogenesisSemantic proximity Read ↗

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