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Article

Using ancestral sequences to uncover potential gene homologues.

Applied bioinformatics - 1 Jan 2003

Collins Lesley J, Poole Anthony M, Penny David

Abstract excerpt

Gene homologues between distantly related species can be difficult to identify. We test the idea that inferred ancestral sequences could aid in finding gene homologues. Ancestral sequences are inferred by aligning gene homologues on a known tree and estimating the most likely amino acid for each position at each node in that tree. BLAST(R) and HMMER are used separately and together with ancestral sequences to...

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PMID: 15130821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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