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<i>Mda‐7</i>/<i>IL‐24</i> induces apoptosis of diverse cancer cell lines through JAK/STAT‐independent pathways

10 Jun 2003

Abstract excerpt

Experimental evidence documents that the MDA-7/IL-24 protein (an IL-10 family cytokine) binds to IL-20 and IL-22 receptor complexes resulting in the activation of JAK/STAT signaling pathways. Recent published reports utilizing human blood derived primary lymphocytes have provided additional confirmatory evidence relating to the cytokine properties of this molecule. A notable attribute of mda-7/IL-24 is its cancer...

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PMID: 12811827
DOI: 10.1002/jcp.10309

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