Article
Single nucleotide polymorphism (-468 Gly to A) at the promoter region of SREBP-1c associates with genetic defect of fructose-induced hepatic lipogenesis [corrected].
The Journal of biological chemistry - 9 Jul 2004
Nagata Ryoko, Nishio Yoshihiko, Sekine Osamu, Nagai Yoshio, Maeno Yasuhiro, Ugi Satoshi, Maegawa Hiroshi, Kashiwagi Atsunori
Abstract excerpt
To evaluate the genetic susceptibility to metabolic disorders induced by high fructose diet, we investigated the metabolic characteristics in 10 strains of inbred mice and found that they were separated into CBA and DBA groups according to the response to high fructose diet. The hepatic mRNA expression of the sterol regulatory element-binding protein-1 (SREBP-1) in CBA/JN was remarkably enhanced by high fructose...
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