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Article

Pervasive developmental disorder and childhood-onset schizophrenia: comorbid disorder or a phenotypic variant of a very early onset illness?

Biological psychiatry - 15 May 2004

Sporn Alexandra L, Addington Anjené M, Gogtay Nitin, Ordoñez Anna E, Gornick Michele, Clasen Liv, Greenstein Deanna, Tossell Julia W, Gochman Peter, Lenane Marge, Sharp Wendy S, Straub Richard E, Rapoport Judith L

Abstract excerpt

BACKGROUND: Childhood-onset schizophrenia (COS) is a severe form of the adult-onset disorder with a high rate of premorbid developmental abnormalities. Early symptoms of pervasive developmental disorder (PDD) have been reported in five independent studies of COS. In this study, we compared evidence for premorbid PDD as a nonspecific manifestation of impaired neurodevelopment seen in schizophrenia, or as an...

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PMID: 15121482
DOI: 10.1016/j.biopsych.2004.01.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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