Article
Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria.
Biological psychiatry - 15 May 2004
Kirov George, Ivanov Dobril, Williams Nigel M, Preece Anna, Nikolov Ivan, Milev Radoi, Koleva Svetlinka, Dimitrova Albena, Toncheva Draga, O'Donovan Michael C, Owen Michael J
Abstract excerpt
BACKGROUND: The gene encoding the dystrobrevin binding protein (DTNBP1) has been implicated in the pathogenesis of schizophrenia by several association studies. We tried to replicate these findings in a sample of 488 parent-proband trios recruited in Bulgaria. Probands had a diagnosis of schizophrenia (n = 441) or schizoaffective disorder (n = 47). METHODS: We genotyped eight single nucleotide polymorphisms...
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