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Identification of Virus-Encoded MicroRNAs

29 Apr 2004

Abstract excerpt

RNA silencing processes are guided by small RNAs that are derived from double-stranded RNA. To probe for function of RNA silencing during infection of human cells by a DNA virus, we recorded the small RNA profile of cells infected by Epstein-Barr virus (EBV). We show that EBV expresses several microRNA (miRNA) genes. Given that miRNAs function in RNA silencing pathways either by targeting messenger RNAs for...

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PMID: 15118162
DOI: 10.1126/science.1096781

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