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Discordant Extracellular Superoxide Dismutase Expression and Activity in Neonatal Hyperoxic Lung

3 May 2004

Abstract excerpt

Antioxidant defenses in the neonatal lung are required to adapt to the oxygen (O(2))-rich postnatal environment, and oxidant/antioxidant imbalance is a predisposition to lung injury when high concentrations of inspired O(2) are used in neonatal lung diseases. The lung's main extracellular enzymatic defense against superoxide, extracellular superoxide dismutase (EC-SOD), is closely regulated during development. In...

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PMID: 15117745
DOI: 10.1164/rccm.200309-1282oc

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