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Article

Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes.

BMC cancer - 12 Mar 2004

Sigurdson Alice J, Hauptmann Michael, Chatterjee Nilanjan, Alexander Bruce H, Doody Michele Morin, Rutter Joni L, Struewing Jeffery P

Abstract excerpt

BACKGROUND: Subtle functional deficiencies in highly conserved DNA repair or growth regulatory processes resulting from polymorphic variation may increase genetic susceptibility to breast cancer. Polymorphisms in DNA repair genes can impact protein function leading to genomic instability facilitated by growth stimulation and increased cancer risk. Thus, 19 single nucleotide polymorphisms (SNPs) in eight genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15113441
DOI: 10.1186/1471-2407-4-9
PMCID: PMC408462

Genes

XRCC1
BRCA2
BRIP1
BRCA1
BACH1
IGFBP3
POLD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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