Article
Mining disease susceptibility genes through SNP analyses and expression profiling using MALDI-TOF mass spectrometry.
Journal of proteome research - 1 Jan 2000
Tang Kai, Oeth Paul, Kammerer Stefan, Denissenko Mikhail F, Ekblom Jonas, Jurinke Christian, van den Boom Dirk, Braun Andreas, Cantor Charles R
Abstract excerpt
To find genes that underlie disease susceptibilities, genome-wide single nucleotide polymorphisms (SNPs) have been analyzed using high-throughput matrix assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS). As a proof-of-concept for this approach, gene regions have been identified that were previously associated by others with certain diseases or traits. On the same technology...
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