Article
Association between polymorphisms of the angiotensin-converting enzyme and angiotensinogen genes and allergic rhinitis in a Korean population.
The Annals of otology, rhinology, and laryngology - 1 Apr 2004
Kim Jeong Joong, Kim Hyun-Ju, Lee Il-Kwon, Chung Hun Taeg, Lee Jae Hoon
Abstract excerpt
Angiotensin-converting enzyme (ACE) inactivates bradykinin, substance P, and neurokinin A, which are thought to play important roles in the pathogenesis of inflammatory diseases. Expression of angiotensinogen, a precursor of angiotensin, is enhanced by augmented secretion of proinflammatory cytokines (eg, interleukin-1) in the site of inflammation. Insertion or deletion (I/D) ACE and M235T angiotensinogen gene...
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