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Article

Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis.

The American journal of pathology - 1 May 2004

Shih Ie-Ming, Kurman Robert J

Abstract excerpt

The pathogenesis of ovarian carcinoma, the most lethal gynecological malignancy, is unknown because of the lack of a tumor progression model. Based on a review of recent clinicopathological and molecular studies, we propose a model for their development. In this model, surface epithelial tumors are divided into two broad categories designated type I and type II tumors that correspond to two main pathways of...

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Identifiers

PMID: 15111296
DOI: 10.1016/s0002-9440(10)63708-x
PMCID: PMC1615664

Genes

KRAS
BRAF
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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