Article
Early detection and treatment of ovarian cancer: shifting from early stage to minimal volume of disease based on a new model of carcinogenesis.
American journal of obstetrics and gynecology - 1 Apr 2008
Kurman Robert J, Visvanathan Kala, Roden Richard, Wu T C, Shih Ie-Ming
Abstract excerpt
The goal of ovarian cancer screening is to detect disease when confined to the ovary (stage I) and thereby prolong survival. We believe this is an elusive goal because most ovarian cancer, at its earliest recognizable stage, is probably not confined to the ovary. We propose a new model of ovarian carcinogenesis based on clinical, pathological, and molecular genetic studies that may enable more targeted screening...
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