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Article

Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems.

Advances in anatomic pathology - 1 Sept 2009

Vang Russell, Shih Ie-Ming, Kurman Robert J

Abstract excerpt

Ovarian serous carcinomas have been graded using various systems. Recently, a 2-tier system in which tumors are subdivided into low grade and high grade has been proposed. This approach is simplistic, reproducible, and based on biologic evidence indicating that both tumors develop via different pathways. Low-grade serous carcinomas exhibit low-grade nuclei with infrequent mitotic figures. They evolve from...

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Source

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Identifiers

PMID: 19700937
DOI: 10.1097/PAP.0b013e3181b4fffa
PMCID: PMC2745605

Genes

BRAF
ERBB2
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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