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Article

Mouse models of infertility due to swollen spermatozoa.

Molecular and cellular endocrinology - 15 Mar 2004

Cooper Trevor G, Yeung Ching-Hei, Wagenfeld Andrea, Nieschlag Eberhard, Poutanen Matti, Huhtaniemi Ilpo, Sipilä Petra

Abstract excerpt

Transgenic mice with male infertility, the c-ros knockout (KO) and GPX5-Tag2 transgenic mouse models, are compared. Both exhibit severely angulated sperm flagella explaining the infertility. As angulated spermatozoa are swollen cells, a failure in volume regulation is indicated. Differences between genotypes were also found: caudal spermatozoa from c-ros KO, but not GPX5-Tag2, could fertilise eggs in vitro;...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infertility, Male

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Source

Identifiers

PMID: 15109745
DOI: 10.1016/j.mce.2003.10.076

Genes

GPX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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