Article
Molecular mechanism investigation of phenobarbital-induced serum cholesterol elevation in rat livers by microarray analysis.
Archives of toxicology - 1 Aug 2004
Kiyosawa Naoki, Tanaka Kohji, Hirao Jun, Ito Kazumi, Niino Noriyo, Sakuma Kyoko, Kanbori Miyuki, Yamoto Takashi, Manabe Sunao, Matsunuma Naochika
Abstract excerpt
Phenobarbital (PB) increases serum total cholesterol levels in rodents and humans. To investigate the underlying molecular mechanisms, we performed a microarray analysis on liver of rats treated repeatedly with 100 mg/kg PB, and examined the serum blood chemistry. The serum concentration of non-esterified fatty acids was decreased from day 1 to day 14 except for day 7, and that of cholesterol was increased from...
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