Article
Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B.
Scientific reports - 14 Feb 2018
Novas Rossina, Cardenas-Rodriguez Magdalena, Lepanto Paola, Fabregat Matías, Rodao Magela, Fariello María Inés, Ramos Mauricio, Davison Camila, Casanova Gabriela, Alfaya Lucía, Lecumberry Federico, González-Sapienza Gualberto, Irigoín Florencia, Badano Jose L
Abstract excerpt
Bardet-Biedl syndrome (BBS) is a ciliopathy characterized by retinal degeneration, obesity, polydactyly, renal disease and mental retardation. CCDC28B is a BBS-associated protein that we have previously shown plays a role in cilia length regulation whereby its depletion results in shortened cilia both in cells and Danio rerio (zebrafish). At least part of that role is achieved by its interaction with the mTORC2...
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