Article
Ideal discrimination of discrete clinical endpoints using multilocus genotypes.
In silico biology - 1 Jan 2004
Hahn Lance W, Moore Jason H
Abstract excerpt
Multifactor Dimensionality Reduction (MDR) is a method for the classification and prediction of discrete clinical endpoints using attributes constructed from multilocus genotype data. Empirical studies with both real and simulated data suggest that MDR has good power for detecting gene-gene interactions in the absence of independent main effects. The purpose of this study is to develop an objective, theory-driven...
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