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Article

Immunohistochemical analysis of hSNF5/INI1 in pediatric CNS neoplasms.

The American journal of surgical pathology - 1 May 2004

Judkins Alexander R, Mauger Joanne, Ht As, Rorke Lucy B, Biegel Jaclyn A

Abstract excerpt

Atypical teratoid/rhabdoid tumor (AT/RT) may be misdiagnosed as primitive neuroectodermal tumor/medulloblastoma (PNET) and occasionally as other tumors. Molecular genetic analysis of AT/RT demonstrates deletion and mutation of the hSNF5/INI1 gene in most cases, with decreased or absent expression at the RNA or protein level. Immunohistochemistry with an antibody to INI1 was performed to determine whether this...

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Share to Chromosomal Proteins, Non-Histone
Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 22

Share to Immunoenzyme Techniques

Share to In Situ Hybridization, Fluorescence

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Source

Identifiers

PMID: 15105654
DOI: 10.1097/00000478-200405000-00013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Immunohistochemical analysis of hSNF5/INI1 in pediatric CNS neoplasms.PMID 15105654Read ↗

Mutations of the INI1 rhabdoid tumor suppressor gene in medulloblastomas and primitive neuroectodermal tumors of the central nervous system.Semantic proximity Read ↗

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Molecular genetics of atypical teratoid/rhabdoid tumor.Semantic proximity Read ↗

INI1 Protein Expression Distinguishes Atypical Teratoid/Rhabdoid Tumor from Choroid Plexus CarcinomaSemantic proximity Read ↗

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Chromosome 22q Deletions in Atypical Teratoid/Rhabdoid Tumors in AdultsSemantic proximity Read ↗

Loss of INI1 protein expression defines a subgroup of aggressive central nervous system primitive neuroectodermal tumors.Semantic proximity Read ↗

Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System: Report on WorkshopSemantic proximity Read ↗

Aberrations of the hSNF5/INI1 gene are restricted to malignant rhabdoid tumors or atypical teratoid/rhabdoid tumors in pediatric solid tumors.Semantic proximity Read ↗

INI1-Deficient TumorsSemantic proximity Read ↗

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