Article
Loss of INI1 protein expression defines a subgroup of aggressive central nervous system primitive neuroectodermal tumors.
Brain pathology (Zurich, Switzerland) - 1 Jan 2013
Miller Suzanne, Ward Jennifer H, Rogers Hazel A, Lowe James, Grundy Richard G
Abstract excerpt
Pediatric embryonal brain tumors can be difficult to classify. Atypical teratoid rhabdoid tumors (ATRT) contain rhabdoid cells, while primitive neuroectodermal tumors (PNETs) are composed of "small round blue cells." Loss of INI1 is a common event in ATRT; therefore, we investigated if the loss of INI1 protein expression was also observed in central nervous system (CNS) PNET and pineoblastoma. A histological...
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