Article
Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2004
Pandya Ashka Y, Talley Lynya I, Frost Andra R, Fitzgerald Thomas J, Trivedi Vivek, Chakravarthy Mithun, Chhieng David C, Grizzle William E, Engler Jeffrey A, Krontiras Helen, Bland Kirby I, LoBuglio Albert F, Lobo-Ruppert Susan M, Ruppert J Michael
Abstract excerpt
PURPOSE: The Krüppel-like transcription factor KLF4/GKLF induces both malignant transformation and a slow-growth phenotype in vitro. Although KLF4 expression is increased in most cases of breast cancer, it was unknown whether these cases represent a distinct subtype with a different clinical outcome. EXPERIMENTAL DESIGN: We examined expression of KLF4 by immunostaining 146 cases of human primary infiltrating...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.