Article
Genes causing inherited cancer as beacons to identify the mechanisms of chemoresistance.
Trends in molecular medicine - 1 Mar 2004
Lønning Per Eystein
Abstract excerpt
Mechanisms of resistance to cancer chemotherapy are poorly understood. Molecular pathways involving genes associated with inherited cancer syndromes could represent mechanisms of chemoresistance. Microarray techniques can identify simultaneous alterations in the mRNA expression of multiple genes, but identification of the exact mechanism responsible for a particular phenotype, including resistance to a specific...
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