Article
The ubiquitin ligase Rsp5p is required for modification and sorting of membrane proteins into multivesicular bodies.
Traffic (Copenhagen, Denmark) - 1 May 2004
Morvan Joelle, Froissard Marine, Haguenauer-Tsapis Rosine, Urban-Grimal Danièle
Abstract excerpt
Precursor forms of vacuolar proteins with transmembrane domains, such as the carboxypeptidase S Cps1p and the polyphosphatase Phm5p, are selectively sorted in endosomal compartments to vesicles that invaginate, budding into the lumen of the late endosomes, resulting in the formation of multivesicular bodies (MVBs). These proteins are then delivered to the vacuolar lumen following fusion of the MVBs with the...
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