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Article

Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S.

Molecular biology of the cell - 1 Feb 2004

Katzmann David J, Sarkar Srimonti, Chu Tony, Audhya Anjon, Emr Scott D

Abstract excerpt

The multivesicular body (MVB) sorting pathway provides a mechanism for delivering transmembrane proteins into the lumen of the lysosome/vacuole. Recent studies demonstrated that ubiquitin modification acts in cis as a signal for the sorting of cargoes into this pathway. Here, we present results from a genetic selection designed to identify mutants that missort MVB cargoes. This selection identified a point...

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Share to Endosomal Sorting Complexes Required for Transport

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Source

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Identifiers

PMID: 14657247
DOI: 10.1091/mbc.e03-07-0473
PMCID: PMC329214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S.PMID 14657247Read ↗

The ubiquitin ligase Rsp5p is required for modification and sorting of membrane proteins into multivesicular bodies.Semantic proximity Read ↗

The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo.Semantic proximity Read ↗

Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins.Semantic proximity Read ↗

Domains of the Rsp5 ubiquitin-protein ligase required for receptor-mediated and fluid-phase endocytosis.Semantic proximity Read ↗

Localization of the Rsp5p ubiquitin-protein ligase at multiple sites within the endocytic pathway.Semantic proximity Read ↗

Characterization of multiple multivesicular body sorting determinants within Sna3: a role for the ubiquitin ligase Rsp5.Semantic proximity Read ↗

Targeting of Sna3p to the endosomal pathway depends on its interaction with Rsp5p and multivesicular body sorting on its ubiquitylation.Semantic proximity Read ↗

Interaction of the deubiquitinating enzyme Ubp2 and the e3 ligase Rsp5 is required for transporter/receptor sorting in the multivesicular body pathway.Semantic proximity Read ↗

Multiple interactions drive adaptor-mediated recruitment of the ubiquitin ligase rsp5 to membrane proteins in vivo and in vitro.Semantic proximity Read ↗

WW domains of Rsp5p define different functions: determination of roles in fluid phase and uracil permease endocytosis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Ubiquitin-mediated targeting of a mutant plasma membrane ATPase, Pma1-7, to the endosomal/vacuolar system in yeast.Semantic proximity Read ↗

Rsp5 ubiquitin ligase is required for protein trafficking in Saccharomyces cerevisiae COPI mutants.Semantic proximity Read ↗

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