Article
A mutant impaired in SNARE complex dissociation identifies the plasma membrane as first target of synaptobrevin 2.
Traffic (Copenhagen, Denmark) - 1 May 2004
Martinez-Arca Sonia, Arold Stefan, Rudge Rachel, Laroche Fabrice, Galli Thierry
Abstract excerpt
Membrane fusion depends on the formation of a complex of four SNARE motifs, three that bear a central glutamine and are localized in the target membrane (t-SNARE) and one that bears an arginine and is localized in the donor vesicle (v-SNARE). We have characterized the arginine 56 to proline mutant (R56P) of synaptobrevin-2 (Sb). SbR56P was blocked at the plasma membrane in association with the endogenous plasma...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.