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Article

The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists.

The Biochemical journal - 6 Jun 2017

Vollmer Stefan, Strickson Sam, Zhang Tinghu, Gray Nathanael, Lee Katherine L, Rao Vikram R, Cohen Philip

Abstract excerpt

We have developed the first assays that measure the protein kinase activities of interleukin-1 receptor-associated kinase 1 (IRAK1) and IRAK4 reliably in human cell extracts, by employing Pellino1 as a substrate in conjunction with specific pharmacological inhibitors of IRAK1 and IRAK4. We exploited these assays to show that IRAK4 was constitutively active and that its intrinsic activity towards Pellino1 was not...

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Share to Interleukin-1 Receptor-Associated Kinases
Share to Interleukin-1beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Monocytes

Share to Myeloid Differentiation Factor 88

Share to Protein Phosphatase 1

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Source

Open in PubMed Open full text

Identifiers

PMID: 28512203
DOI: 10.1042/BCJ20170097
PMCID: PMC5460469

Genes

IRAK4
IRAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

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The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists.PMID 28512203Read ↗

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