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Article

Expression and Role of Gonadotropin-Releasing Hormone 2 and Its Receptor in Mammals

11 Dec 2017

Abstract excerpt

Gonadotropin-releasing hormone (GnRH1) and its receptor (GnRHR1) drive mammalian reproduction via regulation of the gonadotropins. Yet, a second form of GnRH (GnRH2) and its receptor (GnRHR2) also exist in mammals. GnRH2 has been completely conserved throughout 500 million years of evolution, signifying high selection pressure and a critical biological role. However, the GnRH2 gene is absent (e.g., rat) or...

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Identifiers

PMID: 29312140
DOI: 10.3389/fendo.2017.00269

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